EVKEEZA Lowdown Brochure

For people 1 year of age and older who have high bad cholesterol (LDL-C) from HoFH

after adding Get the lowdown on staying lower *

Chloe, Chris, and Peter, who have homozygous familial hypercholesterolemia (HoFH)

*In a clinical study of 64 patients with HoFH aged 12 years and older, the average LDL-C reduction was maintained through 48 weeks.

LDL-C=low-density lipoprotein cholesterol.

INDICATION EVKEEZA is an injectable prescription medicine used along with diet and exercise and other low-density lipoprotein-cholesterol (LDL-C) lowering medicines to lower LDL-C in adults and children 1 year of age and older with a type of high cholesterol called homozygous familial hypercholesterolemia (HoFH). It is not known if EVKEEZA is safe and effective in children under 1 year of age. IMPORTANT SAFETY INFORMATION Do not use EVKEEZA if you are allergic to evinacumab-dgnb or to any of the ingredients in EVKEEZA.

Please see additional Important Safety Information on following pages and click here for full Prescribing Information, including Patient Information.

Finding support on your EVKEEZA ® (evinacumab-dgnb) journey Once you’ve added EVKEEZA to your treatment plan, and your labs show that it’s working for you, it can inspire you to hold on to your drop in bad cholesterol (LDL-C) from HoFH. This drop in LDL-C is yours, and it’s a result of your commitment and the actions you’ve taken to advance toward your goals.

Why staying on your cholesterol-lowering treatments matters HoFH is a serious condition that begins even before birth and makes the body unable to clear bad cholesterol (LDL-C). This condition runs in your family and is caused by changes, or mutations, in the LDL receptor gene or other related genes. With these mutations, LDL receptors cannot effectively remove LDL from the bloodstream to help keep cholesterol levels in a typical range. You may not be able to control your genetics, but you can take action to control your genetically high cholesterol due to HoFH.

EVKEEZA can build on the results you’ve worked so hard to achieve

EVKEEZA can be an important part of your ongoing treatment plan because it works differently from your other prescribed cholesterol-lowering medications. Each medication plays a role in keeping your LDL-C lower.

EVKEEZA reduced bad cholesterol by nearly 50% after 6 months in adults* and children 5 years and older † when added to other cholesterol-lowering treatments.

A key partner and source of support You may receive EVKEEZA at a different location from where your healthcare provider helps manage your cholesterol. Even if you do, your healthcare provider is still there to support you and answer any questions you may have and can stay updated on your treatments.

Individual results may vary.

IMPORTANT SAFETY INFORMATION (continued) Before receiving EVKEEZA, tell your healthcare provider about all of your medical conditions, including if you: • Are breastfeeding or plan to breastfeed. It is not known if EVKEEZA passes into your breast milk. You and your healthcare provider should decide if you will receive EVKEEZA or breastfeed. *At the beginning of the clinical trial, 65 patients with HoFH were enrolled (43 people for EVKEEZA, 22 people for placebo). Participants’ average treated bad cholesterol at baseline was 255 mg/dL. Patients were also receiving other lipid-lowering treatments, including maximally tolerated statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor antibodies, lomitapide, and lipoprotein apheresis. Patients on EVKEEZA had an average 49% reduction in their bad cholesterol at 6 months compared with placebo. † The clinical trial enrolled 20 patients with HoFH, 14 were evaluated for treatment efficacy. The average treated bad cholesterol at baseline was 264 mg/dL. Patients were also receiving other lipid-lowering treatments, including statins, ezetimibe, lomitapide, and lipoprotein apheresis. Patients on EVKEEZA had an average 48% reduction in their bad cholesterol at 6 months. Stay on EVKEEZA and your other cholesterol-lowering medicines to maintain your LDL-C results These treatments can help lower your LDL-C, but this reduction is not permanent. Since HoFH is a lifelong condition, it’s important to continue managing it with ongoing treatment.

Stay in touch with your healthcare provider to track your LDL-C results over time.

IMPORTANT SAFETY INFORMATION (continued) Before receiving EVKEEZA, tell your healthcare provider about all of your medical conditions, including if you: • Are pregnant or plan to become pregnant. EVKEEZA may harm your unborn baby. Tell your healthcare provider if you become pregnant while using EVKEEZA. People who are able to become pregnant: • Your healthcare provider may do a pregnancy test before you start treatment with EVKEEZA. • You should use an effective method of birth control during treatment and for at least 5 months after the last dose of EVKEEZA. Talk with your healthcare provider about birth control methods that you can use during this time. HoFH=homozygous familial hypercholesterolemia; LDL-C=low-density lipoprotein cholesterol. *This is an estimate based on an analysis of patients enrolled in myRARE ® and receiving EVKEEZA through a specialty pharmacy from February 2021 through March 31, 2024, in which 82% of patients received a shipment 12 months after their initial shipment. Patients who did not receive EVKEEZA through a specialty pharmacy are not included in the analysis.

Please see additional Important Safety Information on following pages and click here for full Prescribing Information, including Patient Information.

Resources to help you stay on track with EVKEEZA ® (evinacumab-dgnb)

Empowering you with the right support Your myRARE ® Patient Navigator will work closely with you to help you maintain access to EVKEEZA throughout your ongoing journey. They can answer questions, help you overcome logistical challenges related to treatment, and connect you with resources.

EVKEEZA is administered every 4 weeks by your healthcare provider, which means you receive 13 treatments per year. As the months go by, sometimes you can lose track of your treatment schedule. That’s why there are resources that can help.

Call 1-877-EVKEEZA (1-877-385-3392) and select option 1. Support is available Monday through Friday, 9 am to 9 pm ET.

EVKEEZA Digital Companion Schedule app notifications to remind you of infusion appointments.

Staying on top of insurance changes Insurance will periodically require reauthorization. During these situations, myRARE ® can work with your healthcare provider to help you navigate the reauthorization process.

myRARE ® text reminders Receive text messages to alert you about upcoming EVKEEZA treatments. To opt in for text reminders, call 1-877-EVKEEZA (1-877-385-3392) and select option 1.

The EVKEEZA Digital Companion is a free app provided in partnership with Redi.Health. Download the Redi.Health app to your phone. Then enter the code evkeeza1 when prompted.

“My experiences with myRARE ® and the specialty pharmacy have been great. They help with insurance issues, and when I needed a new home infusion nurse, they made things very easy for me.” — Chris, who has HoFH and has been on EVKEEZA since 2016 (as part of the EVKEEZA clinical study)

Earn milestone belts Milestone belts are awarded by doing tasks such as logging completed EVKEEZA infusions or confirming that you went to a previously scheduled appointment. You can progress from a white belt to a black belt over time by staying on your treatment routine, as appropriate and prescribed by your healthcare provider. The EVKEEZA Digital Companion features a range of tools, such as an LDL-C log, the EVKEEZA treatment tracker, resources and education, access to your support team, and more.

Not an actual patient.

Moving, changing jobs, or retiring from work? This may mean changes to your health insurance coverage, including covered options for where to receive your EVKEEZA infusions. With myRARE ® support, you and your healthcare provider can understand how to maintain coverage for EVKEEZA.

A desktop version is also available at app.redi.health Users must be 13 years of age or older to register for the EVKEEZA Digital Companion. The Redi.Health platform is intended for users over the age of 13, and Redi.Health does not knowingly collect personal information from children under the age of 13.

Missed an EVKEEZA infusion?

“Planning in advance is the key. I plan two months in a row. This way, if something happens, I have time to tell the nurse so we can reschedule.”

IMPORTANT SAFETY INFORMATION (continued) Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Please see additional Important Safety Information on following pages and click here for full Prescribing Information, including Patient Information.

— Carolina, who has HoFH and has been on EVKEEZA since 2018 (as part of the EVKEEZA clinical study)

Infusion insights to enhance your experience If you’re already having a great experience with your infusion routine, keep doing what’s working well! Here are some tips and tricks that have made a difference for others. Preparing for an EVKEEZA ® (evinacumab-dgnb) infusion Wearing comfortable and loose clothing can help make it easier to set up your EVKEEZA infusion. These tips can also help:

Strategies and support for you and your loved ones Fresh ideas to help keep your EVKEEZA routine interesting An EVKEEZA intravenous (IV) infusion lasts for approximately 60 minutes. Here are some new ideas to consider while you’re in the infusion chair:

Watching TV Unwind with your favorite shows or movies

Reading Catch up on books or invite a loved one to read while you listen

Keep warm and cozy, especially your arms. Room temperature can vary, so bring or wear an extra layer to stay comfortable.

Music Listen to music playlists with relaxing songs and sounds

Meditation Try apps for guided meditations to keep your mind focused

Staying hydrated (drinking water) can make it easier to find your veins. Talk to your healthcare provider if you have any medical restrictions that limit fluids.

Podcasts Find a good podcast about a topic you enjoy

Journaling Write down your feelings or track your progress toward your goals

Find a routine that works for you

“Looking at the positives, like spending time with my dad, . . . it keeps your spirits up and makes you want to do the treatments.” — Chloe, who has HoFH and has been on EVKEEZA since 2021

Tips for family members and caregivers You can play a key role in making your loved one’s EVKEEZA journey a more positive experience by providing emotional support.

“We have this tradition where we always stop and get breakfast and coffee [before her EVKEEZA treatments].” — Scott, Chloe’s dad

Write a letter to your loved one Craft a heartfelt note they can read during their next infusion or to stay motivated when times are tough.

Not actual patients.

IMPORTANT SAFETY INFORMATION (continued) EVKEEZA can cause serious side effects, including:

Celebrate small victories Recognize important treatment milestones and goals together.

• Allergic reactions (hypersensitivity), including a severe reaction known as anaphylaxis. Tell your healthcare provider right away if you get any of the following symptoms: swelling (mainly of the lips, tongue or throat which makes it difficult to swallow or breathe), breathing problems or wheezing, feeling dizzy or fainting, rash, hives, and itching.

Please see additional Important Safety Information on following pages and click here for full Prescribing Information, including Patient Information.

Support for sticking to your goal Sometimes, all the motivation you need to move forward is looking back at how far you’ve come. No matter where you are in your treatment journey, support is here to help guide you along the way. Redefine what’s ahead as you work with your healthcare team and your loved ones to set goals for yourself that inspire you to maintain your EVKEEZA Drop in LDL-C.* An important part of sticking to your goals is staying on EVKEEZA and your other cholesterol-lowering medicines along with finding support from myRARE ® .

“Keep going. You are hope and inspiration to others that HoFH can’t hold you down unless you allow it.” — Angel, who has HoFH and has been on EVKEEZA since 2021

*In a clinical study of 64 patients with HoFH aged 12 years and older, the average LDL-C reduction was maintained through 48 weeks.

Speak one-on-one with an EVKEEZA mentor Ask questions and hear their personal story about making EVKEEZA a part of their ongoing cholesterol-lowering treatment routine. You must be 18 years or older to participate.

Call 1-844-890-8588

Find support from the HoFH community Join an HoFH Cholesterol Connections virtual event to learn about HoFH and EVKEEZA. You’ll also hear from someone who is maintaining their lower LDL-C after adding EVKEEZA and feels inspired to share their experience.

IMPORTANT SAFETY INFORMATION (continued) The most common side effects of EVKEEZA include symptoms of the common cold, flu-like symptoms, dizziness, runny nose, nausea, and feeling tired or weak. Tell your healthcare provider if you have any side effect that bothers you or does not go away. These are not all the possible side effects of EVKEEZA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Please click here for full Prescribing Information, including Patient Information.

Date of first EVKEEZA treatment:

reasons to celebrate

My current labs:

My “why”:

Lean on your loved ones and your healthcare team for support.

They can also help you stay motivated, so consider sharing your reasons to celebrate with them!

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® are registered trademarks of Regeneron Pharmaceuticals, Inc. ©2024 Regeneron Pharmaceuticals, Inc. ® are registered trademarks of Regeneron Pharmaceuticals, Inc. ©2025 Regeneron Pharmaceuticals, Inc.

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